Improve Focus, Memory, and Attention in Children (for Kids)
Plasma growth hormones, P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting: evidence supported by structural equation modeling (SEM) parameter estimates.
Braverman ER, Chen TJ, Prihoda TJ, Sonntag W, Meshkin B, Downs BW, Mengucci JF, Blum SH, Notaro A, Arcuri V, Varshavskiy M, Blum K.
PATH Research Foundation, New York, NY, USA.
A review of the literature in both animals and humans reveals that changes in sex hormone have often been associated with changes in behavioral and mental abilities. Previously published research from our laboratory, and others, provides strong evidence that P300 (latency) event-related potential (ERP), a marker of neuronal processing speed, is an accurate predictor of early memory impairment in both males and females across a wide age range. It is our hypothesis, given the vast literature on the subject, that coupling growth hormones (insulin-like growth factor-I, (IGF-I) and insulin-like growth factor binding protein 3 (IGF-BP3)), P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting. To support this hypothesis, we utilized structural equation modeling (SEM) parameter estimates to determine the relationship between aging and memory, as mediated by growth hormone (GH) levels (indirectly measured through the insulin-like growth factor system), P300 latency and TOVA, putative neurocognitive predictors tested in this study. An SEM was developed hypothesizing a causal directive path, leading from age to memory, mediated by IGF-1 and IGF-BP3, P300 latency (speed), and TOVA decrements. An increase in age was accompanied by a decrease in IGF-1 and IGF-BP3, an increase in P300 latency, a prolongation in TOVA response time, and a decrease in memory functioning. Moreover, independent of age, decreases in IGF-1 and IGF-BP3, were accompanied by increases in P300 latency, and were accompanied by increases in TOVA response time. Finally, increases in P300 latency were accompanied by decreased memory function, both directly and indirectly through mediation of TOVA response time. In summary, this is the first report utilizing SEM to reveal the finding that aging affects memory function negatively through mediation of decreased IGF-1 and IGF-BP3, and increased P300 latency (delayed attention and processing speed).
Adv Ther. 2006 Jul-Aug;23(4):582-600.
We inherit much of our brain chemistry from our parents. Often, due to the deficiency in the parent, certain brain chemicals that are passed on to the child are low from birth.
It is interesting to note that such deficiencies can affect each person differently. For instance, in the case of serotonin, one family member may experience anxiety as a result of their low level, while another family member could be overweight if their level is low.
When it comes to the neurotransmitters that affect memory, dopamine levels play a large role. Deficiencies in this neurotransmitter generally cause different problems due to age. In a young child, a low level of the neurotransmitter dopamine may cause focus issues. In an adult, it may present itself in the form of poor concentration, lack of focus, and fogginess; an older adult may experience this lack as memory loss. Studies have shown that when the amino acids that create dopamine are removed from a diet, memory issues and spatial relation issues occur.
Our memory is facilitated by brain chemicals called neurotransmitters. When these brain chemicals are low or out of balance, memory issues can ensue. A complex synergy occurs and many factors like diet come into play. The brain needs a unique combination of specific, concentrated nutrients to nourish it, as well as good fats to help conduct these neurotransmitters along our nerve connection.
Reward Deficiency Solutions Systems
- Find out if you or your children have a genetic predisposition to RDS
- How to eliminate negative RDS behaviors; Stress, Craving, Depression or Anxiety
Dr. Blum and Dr. Waite advocated a non-specific "healthy diet" and non-specific regular exercise to accompany a regimen of taking SynaptoseTM, the nutrigenomic neuroadaptogen they developed based on Dr. Blum's many years of research to increase the endogenous production of Dopamine and reduce negative Reward Deficiency Syndrome behaviors. The scientific evidence they have thus far accumulated, they say, demonstrates that SynaptoseTM changes the plasticity of the brain synapses while balancing the endogenous neurotransmitters, positively affecting the Brain Reward Cascade.