How Psychogenetics &
Nutrigenomics Began
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Reward Deficiency Solutions Systems
- Find out if you or your children have a genetic predisposition to RDS
- How to eliminate negative RDS behaviors; Stress, Craving, Depression or Anxiety
Reward Deficiency Syndrome (RDS) Nutrigenomic Solutions
There have been various companies emerge in the chase to define genes and nutrition. First, there is a difference between terms that are often times used interchangeably. Like pharmacogenetics uses genetic information to choose or dose medications versus pharmacogenomics which uses pharmaceuticals to change genetic information, there is a similar difference between "nutrigenetics" and "nutrigenomics".
Nutrigenetics has been defined as the science of identifying and characterizing gene variants associated with differential responses to nutrients, and relating this variation to disease states. (Mutch D, et al. (2005) FASEB Journal 19:1602-1616.) Others have said nutrigenetics examines the effect of genetic variation on the interaction between diet and exercise. This includes... gene variants associated with, or responsible for, differential responses to nutrients. (Ordovas J & Mooser M. (2004) Current Opinion in Lipidology,15:101-108.) Coming from a perspective of years of research and practical experience implementing pharmacogenetic technologies which are nutrigenetics' analogue, nutrigenetics can be simply defined as using genetic information to choose nutrients or to guide the serving size of nutrients. It is a form of decision-making using genetic information. Nutrigenomics has been defined as the use of functional genomic tools to probe a biological system following a nutritional stimulus that will permit an increased understanding of how nutritional molecules affect metabolic pathways and homeostatic control (Mutch D, et al. (2005) FASEB Journal 19:1602-1616.) Others have said nutrigenomics focuses on the effect of nutrients on the genome, proteome, and metabolome (Ordovas J & Mooser M. (2004) Current Opinion in Lipidology,15:101-108). Simply put, nutrigenomics is a genetic result of a nutrient's use. It is the genetic "effect" of the nutrient and nutrigenetics is the genetic "cause" of the decision to use a nutrient.
With the emergence of this new field of science, there have been some early commercial players. Even though RDSolutions entry into this market is not a "first-mover" commercially, our research efforts long precede these earlier commercial enterprises and it shows in their approach. For the purposes of this paper, we will refer to the overall field as "nutrigenomics", as most of these companies claim to be so, though they do not fit into the very simple and accurate definitions aforementioned.
There are some Nutrigenomic companies that only utilized gene information to 'qualify' a person for standardized diets, dietary supplements, or nutritional guidelines. Other companies use this information to identify an ingredient which changes that gene's expression or explains its mechanism of action. Thus, the gene becomes the target of a specific standard ingredient with a defined mechanism of action. Thus the gene is used to identify an ingredients mechanism of action.
These previous approaches are dated in their approach and there is a paucity of data to actually support their science. RDSolutions, on the other hand, is a very different approach. Compared to the "one-size-fits-all" approach of "qualification" or "identification," RDSolutions employs an approach of using genetic information to customize nutrients and their amounts to actually deliver a physiological change in the person by changing the genetic activity. The approach offered by RDSolutions is "customization." RDSolutions uses genetic information to customize the mechanism of action from a single ingredient or set of ingredients to deliver a treatment outcome. RDSolutions core technology is protected in U.S. Patents. Long before these other commercial enterprises were even incorporated, RDSolutions scientists were researching, conducting studies, and publishing data to deliver on the promise of nutrigenomics.
Upregulation vs. Downregulation
The primary difference between the "Nutrigenomic" products and "Pharmacogenomics" is up and down regulation. Up regulation is where there is a natural increase of the cellular component or physiological function. Down regulation is the process by which a cell decreases the quantity of a cellular component or physiological function.
RDSolutions "nutrigenomic" products assist the body to up regulate their natural supply of Dopamine to normal levels without excess, thus avoiding negative side-effects. When pharmaceutical medications are utilized they slow down or stop the natural cellular production or physiological function while increasing negative side effects. This is the reason why the "Dopamine Agonist" in RDSolutions Synaptose is over-the-counter (OTC) safe.
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- Find out if you or your children have a genetic predisposition to RDS
- How to eliminate negative RDS behaviors; Stress, Craving, Depression or Anxiety
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Dr. Blum and Dr. Waite advocated a non-specific "healthy diet" and non-specific regular exercise to accompany a regimen of taking Synaptose
TM
, the nutrigenomic neuroadaptogen they developed based on Dr. Blum's many years of research to increase the endogenous production of Dopamine and reduce negative Reward Deficiency Syndrome behaviors. The scientific evidence they have thus far accumulated, they say, demonstrates that Synaptose
TM
changes the plasticity of the brain synapses while balancing the endogenous neurotransmitters, positively affecting the Brain Reward Cascade.
