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RDS Breakthrough In Obesity Treatment Inks New Chapter In Neurogoenetics
Much has been written about Dr. Blum's seminal discovery of the "Reward Gene." In-fact over twenty-seven hundred scientific papers linked to Dr. Kenneth Blum and the reward gene have been published. Yet, according to the world renowned neurogeneticist, none will compare in scope or significance to what he is about to reveal in the 2010 March Issue of Postgraduate Medicine (postgradmed.com).
Among the findings Dr. Blum unveiled nearly twenty-years ago, was the Dopamine Receptor D2 (DRD2) gene A1 Allele's inability to effectively process dopamine - the primary neurotransmitter of reward and pleasure. Consequently, people with this gene variant experience the emotional opposite of "well-being." Their biochemistry inhibits their ability to derive reward from ordinary, everyday activities - a condition coined by Blum as 'Reward Deficiency Syndrome' (RDS). Unwittingly, these people found that by consuming large qualities of food (especially sugary foods and refined carbs), alcohol, drugs and/or other external stimulants that they were able to spike their dopamine levels and achieve a temporary emotional state of well-being and happiness. More times than not, the protracted unabated cycle of over-indulgence results in addiction to one or more dopamine activators.
Soon after Dr. Blum's ground-breaking findings were published, geneticists worldwide recognized its potential in combating the food addictions causing obesity. Two opposing theories emerged. For years, a handful of scientists mistakenly believed the approach to be eliminating the euphoria one experienced by starving the brain's reward site of dopamine through the manipulation of other vital neurotransmitters. Conversely, Dr Blum instinctively knew the answer rested squarely on satisfying the cravings by flooding the reward center with super-sized portions of safe natural dopamine activators.
Drawing from his decades of pioneering genetic research, Blum realized there was no 'one-size fits all' solution and set out to develop a new innovative nutrigenomic program designed specifically to combat obesity. He envisioned a personalized approach - something never tried before. He saw that a customized nutraceutical regimen of the dopamine activators could be directed by an individual's specific needs as determined by their DNA. Blum explored the notion that he could reduce the cravings considerably by increasing the D2 receptors with Dopamine activators.
To achieve his goal, Dr. Blum enlisted the assistance of specialists whose names read like the 'Who's Who' in genetics, such as Psychiatrists, Neuroscientists, and Addiction Specialists: E.P. Noble, D.E. Comings, E. Stice, M.S. Gold, M. Oscar-Berman, A. Bowirrat, T. Palomo, George Uhl, Eliot Gardner, John Giordano, and many others to confirm his groundbreaking findings.
Years of research and laboratory experiments produced the first ever nutrigenomic program (KB220) directed by - and designed specifically to - an individuals DNA. The clinical test results proved Dr Blum's concepts to be true. Bariatric measures including binge eating, glucose craving, weight loss and stress of obese patients who were administered customized KB220, based on their gene variant expressions, differed significantly from those administered a placebo.
The findings provide important information that - following a series of additional studies on food as an addictive substance just like other drugs of abuse - could ultimately lead to significant improvement of recovery for victims of Reward Deficiency Syndrome. By any measure, the KB220 neuro-nutragenomic technology proved a resounding success, yet Dr. Blum and his group we not completely satisfied. They decided to put this new technology to the most challenging of tests a neurogoeneticist could have ever imagined; Meth addicts. Methamphetamine is very corrosive to brain function. It is an accepted fact that brains of methamphetamine addicts remain abnormal after many months of abstinence with remarkable dopamine dysfunction making it one of the worst psychoactive substances to abuse.
Dr. Blum conducted the clinical trials with John Giordano, PhD (Hon) Co-founder and Clinical Director of G & G Holistic Addiction Treatment Center in North Miami Beach, Florida. Their stated goal was "normalizing" the reward circuitry site. Methamphetamine addicts (in recovery and not using) were administered a customized variant of the KB220 orally. The preliminary results clearly show substantial and dramatic improvement. The qEEG scans are bright red and blue with brain activity in areas that just hours before were as black and dead as coal - an overwhelming success.
Cameron Allen, a nationally recognized expert in qEEG recordings of Synaptic Connections Inc., pointed out that he has never seen such a profound change toward normality with only one acute treatment of KB220. He said "if further research on KB220 continues to show these same promising results, then this natural Dopaminergic agonist will have benefits especially when coupled with Neurofeedback using specific guidelines and protocols to treat obesity."
The significance of this multi-layered breakthrough cannot be overstated. The importance of this discovery to the tens of millions of people - targeted by these studies - who are suffering from harsh effects of obesity including the negative feelings of guilt - is unimaginable. For the first time in the history of medicine, these people will have access to a nutrigenomic solution that addresses the root cause of their disease and - by all available measures - provides the great potential for a positive outcome.
While this discovery alone is considerable in its own right, the implications from the methodology of the study are profoundly greater. For the first time ever, qEEGs provide the indisputable empirical data proving that the 'excessive' demands of variant gene expressions have been successfully corrected by isolating the variant and treating it with a safe natural Dopaminergic activator (KB220). Dr. Blum and his colleagues have written the guidelines for an entirely new chapter in genetic science. The possibilities are as vast for neurogoeneticists as they are for humanity. The future of neurogenetics is limited only by the imagination of those who embrace this new science.
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Dr. Kenneth Blum retired after 23 years as a Full Professor of Pharmacology at the University Of Texas Health Science Center, San Antonio. His research has been published in over 400 articles relating to toxicology, nutrition and neuropychopharmacogenetics in peer-reviewed scientific journals, including the Journal of the American Medical Association (JAMA), Lancet, Nature, and Science. Dr. Blum was the lead discoverer of the first gene associated with alcoholism, credited with identifying the "Reward Cascade" and coined the term "Reward Deficiency Syndrome". Dr Blum is currently the Chairman of the Board of Reward Deficiency Solutions; headquartered in San Diego, California.
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Reward Deficiency Solutions Systems
- Find out if you or your children have a genetic predisposition to RDS
- How to eliminate negative RDS behaviors; Stress, Craving, Depression or Anxiety
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Dr. Blum and Dr. Waite advocated a non-specific "healthy diet" and non-specific regular exercise to accompany a regimen of taking Synaptose
TM
, the nutrigenomic neuroadaptogen they developed based on Dr. Blum's many years of research to increase the endogenous production of Dopamine and reduce negative Reward Deficiency Syndrome behaviors. The scientific evidence they have thus far accumulated, they say, demonstrates that Synaptose
TM
changes the plasticity of the brain synapses while balancing the endogenous neurotransmitters, positively affecting the Brain Reward Cascade.
